Determining an exact number is challenging as it largely relies on the network topology designed by the cloud service provider. However, if we estimate the average scenario: Within the source region, the packet might pass through routing tables or firewalls, leading to 1-2 hops. It could then connect to an internal backbone network, potentially resulting in another 1-2 hops. Upon arriving at the destination region, it would again need to navigate through similar region-specific routing processes, adding an additional 1-2 hops. Thus, generally speaking, we could estimate that it takes about 3 to 6 hops for a virtual machine in one region to communicate with another in a different region. However, this can vary depending on the cloud provider, the specific network setup, the distance between regions, and other factors. This is a broad and simplified overview, as real-world situations may become more intricate due to the involvement of Content Delivery Networks (CDNs), edge locations, and other acceleration technologies.