Principal Software Engineer

The Regeneron Genetics Center is one of the largest human genetics sequencing programs in the world. We study human DNA at massive scale to understand why diseases happen and how we can stop them. Using genetics to improve human health, our research has contributed directly to medicines helping patients today.

The RGC IT team builds and maintains shared services, platform tooling, and APIs that our research teams depend on. We approach development with an AI-first mindset, utilizing LLM-powered tooling to move faster, explore more ideas and quickly turn complex problems into working solutions for our scientists. A Typical Day As a Principal Software Engineer, you’ll contribute to: API and service development across a shared platform that research teams use to access and work with large-scale genetic data.

Cloud-based data pipeline work on AWS, keeping high-volume genomic data moving reliably and performantly. Integrating and applying AI tooling across development workflows — from LLM-assisted coding and review to building AI-powered capabilities into the platform itself. Working directly with scientists and engineers to understand requirements and deliver meaningful solutions to improve our scientific discovery process.

This Role Might Be for You If You Have: Strong fundamentals at the API and data layer. You’ve built production APIs, integration services, and pipelines in the cloud as microservices. Comfortable with AI-first development.

You use tools like Claude Code as a core part of how you work — not occasionally, but throughout planning, implementation, and review. Technical depth across the stack. API design patterns, distributed systems, cloud-native development on AWS — you can contribute without needing everything handed to you.

Works well as part of a team. Decisions here are collaborative. You do good work in that kind of environment.

Takes quality seriously. You write things that can be tested and maintained, and you know why that matters at scale. To be considered for this opportunity, you must have a Bachelor’s Degree or higher with at least 6 years of relevant IT experience building cloud-native applications.

Candidates must have hands-on experience with: Languages & Runtimes: Python, TypeScript API & Integration: REST API design and development, service integration patterns AI Tooling: LLM-assisted development tools (e.g. Claude Code, GitHub Copilot), AI/ML service integration Data & Databases: PostgreSQL or MySQL, Redshift or Snowflake, ETL orchestration Infrastructure: Docker, AWS cloud services Does this sound like you? Apply now to take your first step towards living the Regeneron Way!

We are committed to building a workplace with an inclusive culture.

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law.

Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship. Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience.

In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits.

For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications. For jobs in Canada: this posting is for an existing position.

Salary Range (annually) $128,600.00 - $210,000.00 Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for over 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to nine FDA-approved treatments and numerous product candidates in development, almost all of which were homegrown in our laboratories.

Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurology, infectious diseases and rare diseases. Regeneron is also proud of award winning culture of innovation, being recognized as a Great Place to Work in 2021, Fast Company’s Best Workplace for Innovators in 2020, and Forbes JUST companies in 2020, among others.